Duplication of Coagulation Factor Genes and Evolution of Snake Venom Prothrombin Activators
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منابع مشابه
Blood Coagulation Induced by Iranian Saw-Scaled Viper (Echis Carinatus) Venom: Identification, Purification and Characterization of a Prothrombin Activator
Objective(s): Echis carinatus is one of the venomous snakes in Iran. The venom of Iranian Echis carinatus is a rich source of protein with various factors affecting the plasma protein and blood coagulation factor. Some of these proteins exhibit types of enzymatic activities. However, other items are proteins with no enzymatic activity. Materials and Methods: In order to study the mechanism ...
متن کاملGene structures of trocarin D and coagulation factor X, two functionally diverse prothrombin activators from Australian rough scaled snake.
Activation of prothrombin to thrombin is the key reaction in blood coagulation cascade. We have recently shown that Australian rough scaled snake, Tropidechis carinatus, possesses two parallel prothrombin activator systems. Trocarin D, a venom prothrombin activator produced in the venom gland, plays an offensive role as a toxin, whereas factor X is produced in the liver and plays a role in the ...
متن کاملClassification and Nomenclature of Prothrombin Activators Isolated from Snake Venoms - On behalf of the Registry of Exogenous Hemostatic Factors of the Scientific and Standardization. Committee of the ISTH
Several prothrombin activators from snake venoms have been isolated and characterized (For details, see 1). Initially, they were classified into three major groups based on their structural and functional properties (1, 2). They differ from each other in their cofactor requirements and the products formed. Group I activators are metalloproteinases. They convert prothrombin to meizothrombin and ...
متن کاملPartial Purification and Characterization of Anticoagulant Factor from the Snake (Echis carinatus) Venom
Objective(s): Snake venoms contain complex mixture of proteins with biological activities. Some of these proteins affect blood coagulation and platelet function in different ways. Snake venom toxin may serve as a starting material for drug design to combat several pathophysiological problems such as cardiovascular disorders. In the present study, purification of anticoagulation facto...
متن کاملBlood Coagulation Induced by Iranian Saw-Scaled Viper (Echis Carinatus) Venom: Identification, Purification and Characterization of a Prothrombin Activator
OBJECTIVE(S) Echis carinatus is one of the venomous snakes in Iran. The venom of Iranian Echis carinatus is a rich source of protein with various factors affecting the plasma protein and blood coagulation factor. Some of these proteins exhibit types of enzymatic activities. However, other items are proteins with no enzymatic activity. MATERIALS AND METHODS In order to study the mechanism and ...
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